There is a growing consensus that results generated through multiplex genetic tests, even those produced as a part of research, should be reported to providers and patients when they are considered “actionable,” that is, when they could be used to inform some potentially beneficial clinical action. However, there remains controversy over the precise criterion that should be used in identifying when a result meets this standard. In this paper, we seek to refine the concept of “actionability” by exploring one proposed (...) use for genetic test results. We argue that genetic test results indicating that a patient is at risk for developing a chronic health condition should not be considered actionable if the only potential value of that result is to motivate patients to make changes in their health behaviors. Since the empirical research currently available on this question is equivocal, we explore relevant psychological theories of human motivation to demonstrate that current theory does not support the assumption that information about genetic risk will be motivating to most patients in their attempts to make changes in health behaviors. (shrink)

This article provides practical guidance for researchers who wish to enroll and collect data from pediatric research participants through online and mobile platforms, with a focus on the involvement of both children and their parents in the decision to participate.

¡Presente! develops a lived theology of nonviolence through an extended case study of the movement to close the School of the Americas (also known as the SOA or WHINSEC). Specifically,it analyzes how the presence of the dead—a presence proclaimed at the annual vigil of the School of the Americas Watch—shapes a distinctive, transnational, nonviolent movement. Kyle B.T. Lambelet argues that such a messianic affirmation need not devolve into violence or sectarianism and, in fact, generates practical reasoning. By developing a (...) messianic political theology in dialogue with the SOA Watch movement, Lambelet's work contributes to Christian ethics as he explores the political implications of the resurrection of the dead. This book contributes to studies of strategic nonviolence and civil resistance by demonstrating how religious and moral dynamics remain an essential part of such struggles. (shrink)

In this paper I take up the ambivalence we rightly feel toward leaders by examining the relationship between charismatic authority and moral exemplarity. Drawing on the social theory of Max Weber, and in dialogue with a case study of an anti-militarism movement called the SOA (School of Americas) Watch, I demonstrate that through a “politics of sacrifice” leaders synchronize their own stories with those of communally recognized exemplars and act in ways that evidence a solidarity in the suffering of those (...) exemplars thereby generating their charismatic authority. While performing crucial strategic, motivational, and pedagogical roles, this charisma also introduces problematic temptations to authoritarianism that short-circuit the practical reasoning that exemplars supposedly help to form. In the end this leaves our sense of ambivalence intact. What is needed, I argue, are practices of critique that reopen the distance between leader and follower and thus allow the possibility of practical reason. (shrink)

The COVID-19 pandemic has resulted in widespread disruption of the typical way of doing things. In nearly every industry, responses to the pandemic have brought about departures from standard opera...

What should we make of the apocalyptic tone taken up by politicians, journalists, scientists, and activists? Some environmental thinkers such as Michael Shellenberger contend that alarming rhetoric distracts us from the technological and governance challenges presented by climate change. In the article, it is argued that retrieving a practical apocalyptic political theology from the Christian tradition can both clarify conceptual contradictions within this discourse as well as offer a practical orientation toward living within ecological endings. Amid the cascade of environmental (...) crises we are living through, apocalyptic practices of renunciation of the world offer a guide and discipline for living in the end. (shrink)

We look to mitonuclear ecology and the phenomenon of Mother’s Curse to argue that the sex of parents and offspring among populations of eukaryotic organisms, as well as the mitochondrial genome, ought to be taken into account in the conceptualization of evolutionary fitness. Subsequently, we show how characterizations of fitness considered by philosophers that do not take sex and the mitochondrial genome into account may suffer. Last, we reflect on the debate regarding the fundamentality of trait versus organism fitness and (...) gesture at the idea that the former lies at the conceptual basis of evolutionary theory. (shrink)

As genomic science has evolved, so have policy and practice debates about how to describe and evaluate the ways in which genomic information is treated for individuals, institutions, and society. The term genetic exceptionalism, describing the concept that genetic information is special or unique, and specifically different from other kinds of medical information, has been utilized widely, but often counterproductively in these debates. We offer genomic contextualism as a new term to frame the characteristics of genomic science in the debates. (...) Using stasis theory to draw out the important connection between definitional issues and resulting policies, we argue that the framework of genomic contextualism is better suited to evaluating genomics and its policy-relevant features to arrive at more productive discussion and resolve policy debates. (shrink)

Mobile devices with health apps, direct-to-consumer genetic testing, crowd-sourced information, and other data sources have enabled research by new classes of researchers. Independent researchers, citizen scientists, patient-directed researchers, self-experimenters, and others are not covered by federal research regulations because they are not recipients of federal financial assistance or conducting research in anticipation of a submission to the FDA for approval of a new drug or medical device. This article addresses the difficult policy challenge of promoting the welfare and interests of (...) research participants, as well as the public, in the absence of regulatory requirements and without discouraging independent, innovative scientific inquiry. The article recommends a series of measures, including education, consultation, transparency, self-governance, and regulation to strike the appropriate balance. (shrink)

Beginning in the 20th century, scientific research came to be dominated by a growing class of credentialed, professional scientists who overwhelmingly displaced the learned amateurs of an earlier time. By the end of the century, however, the exclusive realm of professional scientists conducting research was joined, to a degree, by “citizen scientists.” The term originally encompassed non-professionals assisting professional scientists by contributing observations and measurements to ongoing research enterprises. These collaborations were especially common in the environmental sciences, where citizen scientists (...) participated in counting wildlife and measuring environmental conditions. Later, patient groups began to play a more active role in supporting clinical trials and collecting health records from affected individuals. (shrink)

Coastal ecosystems are increasingly dominated by humans. Consequently, the human dimensions of sustainability science have become an integral part of emerging coastal governance and management practices. But if we are to avoid the harsh lessons of land management, coastal decision makers must recognize that humans are one of the more coastally dependent species in the biosphere. Management responses must therefore confront both the temporal urgency and the very real compromises and sacrifices that will be necessary to achieve a sustainable coastal (...) ecosystem, one that is economically feasible, socially just, and ecologically sound. (shrink)

Der Aufsatz analysiert den Konnex zwischen Individualisierter Medizin und der Forderung nach mehr gesundheitlicher Eigenverantwortung, der oft als plausibel angenommen wird, wenn der Individualisierten Medizin das Potential zugesprochen wird, das solidarisch finanzierte Gesundheitssystem in Deutschland zu transformieren. Ausgehend von einer logischen Rekonstruktion des Verantwortungsbegriffs, die dessen Operationalisierbarkeit unter anderem an Sanktionsvollmachten der jeweiligen Verantwortungsinstanz bindet, und basierend auf einem terminologisch präzisierten Verständnis von Individualisierter Medizin wird folgende These entwickelt: Die Annahme, im Rahmen Individualisierter Medizin sei eine verlässliche Prädiktion anlagebedingter und (...) zugleich lebensstilabhängiger Erkrankungsrisiken möglich, verpflichtet logisch nicht zur Übernahme der Forderung, Lebensstile mit negativem Einfluss auf persönliche Erkrankungsrisiken seien zu sanktionieren. Weil die Forderung nach mehr gesundheitlicher Eigenverantwortung aus dem Programm der Individualisierten Medizin logisch nicht ohne Hinzunahme normativer Prinzipien abzuleiten ist, kann man dieses Programm selbst gut heißen, ohne sich die politische Forderung nach einem Umbau des solidarisch finanzierten Gesundheitssystems unter dem Vorzeichen gesundheitlicher Eigenverantwortung zu eigen machen zu müssen. (shrink)

ZusammenfassungDer Aufsatz analysiert den Konnex zwischen Individualisierter Medizin und der Forderung nach mehr gesundheitlicher Eigenverantwortung, der oft als plausibel angenommen wird, wenn der Individualisierten Medizin das Potential zugesprochen wird, das solidarisch finanzierte Gesundheitssystem in Deutschland zu transformieren. Ausgehend von einer logischen Rekonstruktion des Verantwortungsbegriffs, die dessen Operationalisierbarkeit unter anderem an Sanktionsvollmachten der jeweiligen Verantwortungsinstanz bindet, und basierend auf einem terminologisch präzisierten Verständnis von Individualisierter Medizin wird folgende These entwickelt: Die Annahme, im Rahmen Individualisierter Medizin sei eine verlässliche Prädiktion anlagebedingter und (...) zugleich lebensstilabhängiger Erkrankungsrisiken möglich, verpflichtet logisch nicht zur Übernahme der Forderung, Lebensstile mit negativem Einfluss auf persönliche Erkrankungsrisiken seien zu sanktionieren. Weil die Forderung nach mehr gesundheitlicher Eigenverantwortung aus dem Programm der Individualisierten Medizin logisch nicht ohne Hinzunahme normativer Prinzipien abzuleiten ist, kann man dieses Programm selbst gut heißen, ohne sich die politische Forderung nach einem Umbau des solidarisch finanzierten Gesundheitssystems unter dem Vorzeichen gesundheitlicher Eigenverantwortung zu eigen machen zu müssen. (shrink)

ZusammenfassungDer Aufsatz analysiert den Konnex zwischen Individualisierter Medizin und der Forderung nach mehr gesundheitlicher Eigenverantwortung, der oft als plausibel angenommen wird, wenn der Individualisierten Medizin das Potential zugesprochen wird, das solidarisch finanzierte Gesundheitssystem in Deutschland zu transformieren. Ausgehend von einer logischen Rekonstruktion des Verantwortungsbegriffs, die dessen Operationalisierbarkeit unter anderem an Sanktionsvollmachten der jeweiligen Verantwortungsinstanz bindet, und basierend auf einem terminologisch präzisierten Verständnis von Individualisierter Medizin wird folgende These entwickelt: Die Annahme, im Rahmen Individualisierter Medizin sei eine verlässliche Prädiktion anlagebedingter und (...) zugleich lebensstilabhängiger Erkrankungsrisiken möglich, verpflichtet logisch nicht zur Übernahme der Forderung, Lebensstile mit negativem Einfluss auf persönliche Erkrankungsrisiken seien zu sanktionieren. Weil die Forderung nach mehr gesundheitlicher Eigenverantwortung aus dem Programm der Individualisierten Medizin logisch nicht ohne Hinzunahme normativer Prinzipien abzuleiten ist, kann man dieses Programm selbst gut heißen, ohne sich die politische Forderung nach einem Umbau des solidarisch finanzierten Gesundheitssystems unter dem Vorzeichen gesundheitlicher Eigenverantwortung zu eigen machen zu müssen. (shrink)

Pietraszewski asserts that social psychological research on groups is too vague, tautological, and dependent on intuitions to be theoretically useful. We disagree. Pietraszewski's contribution is thought-provoking but also incomplete and guilty of many of the faults he attributes to others. Instead of rototilling the existing knowledge landscape, we urge for more integration of new and old ideas.

Ideas for How to Take Wicked Problems Seriously Content Type Journal Article Pages 1-5 DOI 10.1007/s10806-011-9348-9 Authors Kyle Powys Whyte, Department of Philosophy, Michigan State University, 503 S. Kedzie Hall, East Lansing, MI 48824, USA Paul B. Thompson, Department of Philosophy, Michigan State University, 503 S. Kedzie Hall, East Lansing, MI 48824, USA Journal Journal of Agricultural and Environmental Ethics Online ISSN 1573-322X Print ISSN 1187-7863.

Psychedelics such as psilocybin reliably produce significantly altered states of consciousness with a variety of subjectively experienced effects. These include certain changes to perception, cognition, and affect,1 which we refer to here as the acute subjective effects of psychedelics. In recent years, psychedelics such as psilocybin have also shown considerable promise as therapeutic agents when combined with talk therapy, for example, in the treatment of major depression or substance use disorder.2 However, it is currently unclear whether the aforementioned acute subjective (...) effects are necessary to bring about the observed therapeutic effects of psilocybin and other psychedelics. This uncertainty has sparked a lively—though still largely hypothetical—debate on whether psychedelics without subjective effects (“nonsubjective psychedelics” or “non-hallucinogenic psychedelics”) could still have the same therapeutic impact, or whether the acute subjective effects are in fact necessary for this impact to be fully realized.3,4,5. (shrink)

Proponents of the problem of animal suffering state that the great amount of animal death and suffering found in Earth’s natural history provides evidence against the truth of theism. In particular, philosophers such as Paul Draper have argued that regardless of the antecedent probability of theism and naturalism, animal suffering provides positive evidence for the truth of naturalism over theism. While theists have attempted to provide answers to the problem of animal suffering, almost none have argued that animal suffering and (...) death can be seen as positive evidence for theism. This essay will discuss several arguments from the writings of Thomas Aquinas that can be used to show that animal suffering and death are to be expected in theistic universes. In the first section, I discuss evidential arguments for naturalism from animal suffering. Next, I provide an overview of Aquinas’ arguments, particularly in Book II of the Summa Contra Gentiles. After this, I discuss the implications these arguments have for theistic universes. Finally, I conclude that these arguments refute evidential arguments for naturalism from animal suffering and also provide evidence that favors theism. (shrink)

Stephen Law’s evil-god challenge is the argument that since an evil god is just as likely as the God of theism, there is no reason to believe that theism is true over believing there is a god who is omnipotent, omniscient, and omnimalevolent. There have been several attempts to answer the challenge, but recently John Collins has defended the evil-god challenge and also extended the argument past Law’s original formulation. In this article, I defend the classical theism of Thomas Aquinas (...) against the evil-god challenge. In particular, I explain how Aquinas’s theodicy involving God’s goodness and Aquinas’s privation view of evil avoid the challenge. (shrink)

Most prions (infectious proteins) are self‐propagating amyloids (filamentous protein multimers), and have been found in both mammals and fungal species. The prions [URE3] and [PSI+] of yeast are disease agents of Saccharomyces cerevisiae while [Het‐s] of Podospora anserina may serve a normal cellular function. The parallel in‐register beta‐sheet structure shown by prion amyloids makes possible a templating action at the end of filaments which explains the faithful transmission of variant differences in these molecules. This property of self‐reproduction, in turn, allows (...) these proteins to act as de facto genes, encoding heritable information. BioEssays 30:955–964, 2008. © 2008 Wiley Periodicals, Inc. (shrink)

Proponents of the problem of animal suffering claim that the millions of years of apparent nonhuman animal pain and suffering provides evidence against the existence of God. Neo-Cartesianism attempts to avoid this problem mainly by denying the existence of phenomenal consciousness in nonhuman animals. However, neo-Cartesian options regarding animal minds have failed to compel many. In this essay, I explore an answer to the problem of animal suffering inspired by the medieval theologian Thomas Aquinas. Instead of focusing on phenomenal consciousness, (...) the neo-Thomistic view of animal minds focuses on self-awareness. After proposing and providing evidence for this view, I conclude that nonhuman animal suffering is not morally significant. (shrink)

Recently the intramural debate among Christians over the correct interpretation of Genesis 1 and the age of the earth has become heated between leaders of certain science-based ministries. A major point of contention revolves around the question of whether there was animal death before Adam and Eve’s first sin. Many young-earth proponents charge that if God allowed death before Adam and Eve sinned, then God would not be morally perfect. In this paper I propose and critique a logical argument from (...) these charges. First, I formulate a logical problem based on the claims of young-earth proponents. Next, I discuss several theistic interpretations of God’s moral perfection and explain how deontological and consequentialist interpretations are problematic. After this I discuss Aquinas’ interpretation of God’s moral perfection. Finally, I provide a solution to the problem of death before the fall using Aquinas’ interpretation. I conclude that it is not logically contradictory to believe that God is all-knowing, all-powerful, and all-good and that He created a world that initially contained animal death. (shrink)

The psychedelic psilocybin has shown promise both as treatment for psychiatric conditions and as a means of improving well-being in healthy individuals. In some jurisdictions (e.g., Oregon, USA), psilocybin use for both purposes is or will soon be allowed and yet, public attitudes toward this shift are understudied. We asked a nationally representative sample of 795 US Americans to evaluate the moral status of psilocybin use in an appropriately licensed setting for either treatment of a psychiatric condition or well-being enhancement. (...) Showing strong bipartisan support, participants rated the individual’s decision as morally positive in both contexts. These results can inform effective policy-making decisions around supervised psilocybin use, given robust public attitudes as elicited in the context of an innovative regulatory model. We did not explore attitudes to psilocybin use in unsupervised or non-licensed community or social settings. (shrink)

The question of whether the existence of evil in the world is compatible with the existence of an all-knowing, all-powerful, all-good God has been debated for centuries. Many have addressed classical arguments from evil, and while recent scholarship in analytic philosophy of religion has produced newer formulations of the problem, most of these newer formulations rely on a conception of God that is not held by all theists. In Bringing Good Even Out of Evil: Thomism and the Problem of Evil, (...) B. Kyle Keltz defends classical theism against contemporary problems of evil through the philosophy of Thomas Aquinas and his interpreters. Keltz discusses Aquinas’s thought on God, evil, and what kind of world God would make, then turns to contemporary problems of evil and shows how they miss the mark when it comes to classical theism. Some of the newer formulations that the book considers include James Sterba’s argument from the Pauline principle, J. L. Schellenberg’s divine hiddenness argument, Stephen Law’s evil-god challenge, and Nick Trakakis’s anti-theodicy. (shrink)

The problem of animal suffering is the atheistic argument that an all-knowing, all-powerful, and all-good God would not use millions of years of animal suffering, disease, and death to form a planet for human beings. This argument has not received as much attention in the philosophical literature as other forms of the problem of evil, yet it has been increasingly touted by atheists since the time of Charles Darwin. While several theists have attempted to provide answers to the problem, they (...) disagree with each other as to which answer is correct. Also, some of these theists have given in to the problem and believe it entails that God is limited in certain ways. B. Kyle Keltz seeks to provide a classical answer to the problem of animal suffering inspired by the medieval philosopher/theologian Thomas Aquinas. In doing so, Keltz not only utilizes the wisdom of Aquinas, but also contemporary insights into non-human animal minds from contemporary philosophy and science. Keltz provides a compelling neo-Thomistic answer to the problem of animal suffering and explains why the classical God of theism would create a world that includes animal death. (shrink)

The problem of animal suffering considers whether God would allow millions of years of animal pain, disease, and death. Philosophers who debate this issue often assume that pain and suffering are evils a loving God would not allow without good reason. Moreover, a considerable amount of the debate regarding the problem of animal suffering involves whether animals are capable of experiencing pain and suffering. But this raises the question of whether pain and suffering are intrinsically evil. In this essay I (...) explore the nature of pain and suffering from a Thomistic perspective. First I briefly explain how the intrinsic values of pain and suffering are crucial regarding the problem of evil and the problem of animal suffering in particular. Next I explain the Thomistic concepts of pain and suffering and show that they do not contradict their contemporary philosophical and scientific counterparts. Afterward I determine whether pain and suffering are intrinsically evil experiences that an all-good God should refrain from causing. I conclude that pain and suffering are not intrinsically evil and that the problem of animal suffering is not a problem in addition to the problem of natural evil. (shrink)

Thomas Aquinas is often mentioned in the debate regarding best possible worlds. Some philosophers believe Aquinas’ writings entail that God must create a best possible world while most think he rejects the notion. Additionally, it is thought that Aquinas’ position falls prey to the problem of no best world. However, a closer examination of Aquinas’ metaphysical views shows that he has been misunderstood in the current debate. In this essay, I first examine some contemporary views regarding Aquinas’ thought on best (...) possible worlds. Afterward, I discuss Aquinas’ concepts of God’s goodness and God’s purpose for creating and determine their implications for his position regarding best possible worlds. Understanding these concepts helps to show why Aquinas’ position has been misrepresented. I conclude that while Aquinas does reject the popular notion of a best possible world, his arguments are not susceptible to the problem of no best world. (shrink)

What is the significance of the wicked problems framework for environmental philosophy? In response to wicked problems, environmental scientists are starting to welcome the participation of social scientists, humanists, and the creative arts. We argue that the need for interdisciplinary approaches to wicked problems opens up a number of tasks that environmental philosophers have every right to undertake. The first task is for philosophers to explore new and promising ways of initiating philosophical research through conducting collaborative learning processes on environmental (...) issues. The second task is for philosophers to recognize the value of philosophical skills in their engagements with members of other disciplines and walks of life in addressing wicked problems. The wicked problems framework should be seen as an important guide for facilitating philosophical research that is of relevance to problems like climate change and sustainable agriculture. Content Type Journal Article Category Articles Pages 1-14 DOI 10.1007/s10806-011-9344-0 Authors Paul B. Thompson, Department of Philosophy, Michigan State University, 503 S. Kedzie Hall, East Lansing, MI 48824, USA Kyle Powys Whyte, Department of Philosophy, Michigan State University, 503 S. Kedzie Hall, East Lansing, MI 48824, USA Journal Journal of Agricultural and Environmental Ethics Online ISSN 1573-322X Print ISSN 1187-7863. (shrink)